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Dr Khuzwayo Jere

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Dr Khuzwayo C. Jere is a Lecturer in the department of Medical Laboratory Sciences in the faculty of Biomedical Sciences and Health Professionals at the College of Medicine (COM), University of Malawi, and also an Honorary Research Fellow at the Institute of Infection and Global Health, University of Liverpool. He leads rotavirus surveillance studies at the Malawi-Liverpool Wellcome Trust Clinical Research Programme (MLW) and is a member of the Vaccine surveillance consortium that is assessing the effectiveness of newly introduced childhood rotavirus and pneumococci vaccines in Malawi. He pursued a BSc. Degree at the University of Malawi, then obtained BSc. (Med)(Hons) and MSc. (Med) degrees in Medical Virology at the Medical University of Southern Africa, Medunsa (now Sefakgo Mahatho Heath Science University), and a PhD in Biochemistry at North-West University in South Africa. Dr Jere has recently been awarded a Wellcome Trust Training Fellowship in Public Health and Tropical Medicine in which he is utilise recent advances in high throughput sequencing technologies to understand immune responses in children exposed to rotavirus.

Before joining COM, Dr Jere worked as a Postdoctoral Research Associate at the University of Liverpool for four years. He also worked as a Postdoctoral Research Fellow and Research Officer at the Diarrhoeal Pathogens Research Unit at Medunsa in Pretoria, South Africa, which is a WHO Reference Laboratory for Rotavirus research in Southern Africa. During this time, he was involved in the pivotal Phase II and III Rotarix rotavirus vaccine clinical trials. Prior to this, he worked as a Graduate Research Scientist at Malawi-Liverpool Wellcome Trust Clinical Research Programme where they examined the immunogenicity of inhaled anti-pneumococcal vaccine. Dr Jere has published several peer-reviewed articles in international journals (ORCID iD:0000-0003-3376-8529) and has supervised a couple of postgraduate students who have graduated with BSc (Med) (Hons) and PhD degrees.

Dr Jere’s current work focuses on understanding the epidemiology, immunology, evolution and the disease burden of enteric pathogens with a special focus on rotaviruses. During his PhD studies, he demonstrated for the first time how to effectively utilise high-throughput sequencing to generate and classify whole genomes of rotaviruses. These methods are now in use across the globe. He also demonstrated, as a proof of concept, how recombinant rotavirus proteins can be engineered from nucleotide sequences generate from rotaviruses directly isolated from clinical specimens. He then assembled these recombinant proteins into chimaeric rotavirus-like particles, which are under consideration as alternative rotavirus sub-unit vaccine candidates.

Dr Jere is a Cannon Collins PhD alumina and during his postgraduate studies, he was awarded several scholarships/research grants from the Poliomyelitis Research Foundation (PRF), National Research Foundation of South Africa (NRF) and the Department of Science and Technology of South Africa. Dr Jere’s current work is funded by grants he received from the Wellcome Trust, GlaxoSmithKline Biologicals and the Centre for Disease Control Foundation, USA. He has active collaborations in the UK (University of Liverpool and University of Glasgow), USA (Centre for Disease Control and Prevention (CDC), Atlanta), India (Christian Medical College, Vellore), South Africa (University of Kwazulu Natal, Kwazulu Natal Research Institute for Tuberculosis and HIV (K-RITH), University of Free State, National Institute for Communicable Diseases (NICD), University of Free State and Sefako Makgatho Health Sciences University) and at the World Health Organization (WHO).

Publications

    1. Bwogi, J.,Jere, K.C.,Karamagi, C., Byarugaba, D.K., Namuwulya, P., Baliraine, F.N., Ulrich Desselberger, U., Iturriza-Gomara, M.A Whole genome analysis of selected human and animal rotaviruses identified in Uganda from 2012 to 2014 reveals complex genome reassortment events between human, bovine, caprine and porcine strains. PLoS One (accepted Under revision)
    2. Hull, J.J., Cunliffe, N.A.,Jere, K.C.,Moon, S-S., Wang, Y., Umesh Parashar, U.D., Jiang, D. Rotavirus antigen, cytokine and neutralizing antibody profiles in sera of children with and without HIV infection in Blantyre, Malawi. Malawi Med J (accepted Dec 2016).
    3. Arana, A., Montes, M., Jere, K.C., Alkorta, M., Iturriza-GA?mara, M., Cilla, G. Emergence and spread of G3P[8] rotaviruses possessing an equine-like VP7 and a DS-1-like genetic backbone in the Basque Country (North of Spain), 2015. Infection, Genetics and Evolution Journal, 2016 Oct;44:137-44.
    4. Nakagomi, T., Do, L.P., Agbemabiese, C.A., Kaneko, M., Gauchan. P., Doan, Y.H., Jere, K.C., Steele, A.D., Iturriza-Gomara, M., Nakagomi, O., Cunliffe, N.A. Whole-genome characterisation of G12P[6] rotavirus strains possessing two distinct genotype constellations co-circulating in Blantyre, Malawi, 2008. Archives of Virology, 2016 Oct 7. [Epub ahead of print]
    5. Bar-Zeev N, Tate JE, Pecenka C, Chikafa J, Mvula H, Wachepa R, Mwansambo C, Mhango T, Chirwa G, Crampin AC, Parashar UD, Costello A, Heyderman RS, French N, Atherly D, Cunliffe NA; VACSURV Consortium*. Cost-Effectiveness of Monovalent Rotavirus Vaccination of Infants in Malawi: A Postintroduction Analysis Using Individual Patient-Level Costing Data. Journal of Clinical Infectious Disease, 2016 May 1;62 Suppl 2:S220-8. * Consortium co-author
    6. Bar-Zeev, N.,* Jere, K.C.,* Bennett, A., Pollock, L., Tate, J.E., Nakagomi, Miren Iturriza-Gomara, M., Costello, A., Mwansambo, C., Parashar, U.D., Heyderman, R.S., Neil French , N., Cunliffe, N.A. Population impact and effectiveness of monovalent rotavirus vaccination in urban Malawian children three years post vaccine introduction: ecological and case-control analyses. Journal of Clinical Infectious Disease, 2016 May 1;62 Suppl 2:S213-9.* Joint first authors.
    7. King C, Zamawe C, Banda M, Bar-Zeev N, Beard J, Bird J, Costello A, Kazembe P, Osrin D, Fottrell E; VacSurv Consortium*. The quality and diagnostic value of open narratives in verbal autopsy: a mixed-methods analysis of partnered interviews from Malawi. BMC Medical Research Methodology. 2016 Feb 1;16:13. * Consortium co-author
    8. King C, Beard J, Crampin AC, Costello A, Mwansambo C, Cunliffe NA, Heyderman RS, French N, Bar-Zeev N; VacSurv Consortium*. Methodological challenges in measuring vaccine effectiveness using population cohorts in low resource settings. 2015 Sep 11;33(38):4748-55. * Consortium co-author
    9. Bennett, A., Bar-Zeev, N., Jere, K.C., Tate, J.E., Parashar, U.D., Nakagomi, O., Heyderman, R.S., French, N., Iturriza-Gomara, M., Cunliffe, N.A. Determination of a Viral Load Threshold To Distinguish Symptomatic versus Asymptomatic Rotavirus Infection in a High-Disease-Burden African Population. Journal of Clinical Microbiology, 2015 Jun; 53(6):1951-4.
    10. Nyaga, M.M., Jere, K.C., Esona, M.D., Seheri, M.L., Stucker, K.M., Halpin, R.A., Akopov, A., Stockwell, T.B., Peenze. I., Diop, A., Ndiaye, K., Boula, A., Maphalala, G., Berejena, C., Mwenda, J.M., Steele, A.D., Wentworth, D.E., Mphahlele, M.J. Whole genome detection of rotavirus mixed infections in human, porcine and bovine samples co-infected with various rotavirus strains collected from sub-Saharan Africa. Infection, Genetics and Evolution Journal. 2015 Apr;31:321-34.
    11. Bar-Zeev, N., Kapanda, L., Tate, J.E., Jere, K.C., Iturriza-Gomara, M., Nakagomi, O., Mwansambo, C., Costello, A., Parashar, U.D., Heyderman, R.S., French, N., Cunliffe, N.A. Impact and effectiveness of monovalent rotavirus vaccine following programmatic roll-out among infants in Malawi. Lancet Infect Dis. 2015 Apr;15(4):422-8.
    12. Nyaga MM, Stucker KM, Esona MD,Jere KC, Mwinyi B, Shonhai A, Tsolenyanu E, Mulindwa A, Chibumbya JN, Adolfine H, Halpin RA, Roy S, Stockwell TB, Berejena C, Seheri ML, Mwenda JM, Steele AD, Wentworth DE, Mphahlele MJ. Whole-genome analyses of DS-1-like human G2P[4] and G8P[4] rotavirus strains from Eastern, Western and Southern Africa.Virus Genes. 2014 Oct;49 (2) :196-207.
    13. Jere, K.C., O Neill, H.G., Potgieter, A. C., van Dijk, A.A. Chimaeric virus-like particles derived from consensus genome sequences of human rotavirus strains co-circulating in Africa. PLos One Sept, 2014, Vol 9(9): e105167
    14. Nyaga, M.M., Esona, M.D., Jere, K.C., Peenze, I., Seheri, M.L., Mphahlele, M.J. Genetic diversity of rotavirus genome segment 6 (encoding VP6) in Pretoria, South Africa. SpringerPlus, April, 2014, Vol 3: 179; p245, 250.
    15. Jere, K.C., Esona, M.D., Ali, Y.H., Peenze, I., Roy, S., Bowen, M.D., Saeed, I.K., Khalafalla, A.I., Nyaga, M.M., Mphahlele, J., Steele, D., Seheri, M.L. Novel NSP1 genotype characterised in an African camel G8P[11] rotavirus strain. Infect Genet Evol, January, 2014, 21: p58 doi: 10.1016/j.meegid.2013.10.002. Epub 2013 Oct 30.
    16. Nyaga, M.M., Jere, K.C., Peenze, I., Mlera, L., van Dijk, A.A., Seheri, M.L., Mphahlele, M.J. Sequence analysis of the whole genomes of five African human G9 rotavirus strains. Infection, Genetics and Evolution Journal. June, 2013, Vol 16: p62
    17. Mlera, L., O’Neill, H.G., Jere, K.C., van Dijk, A.A. Whole-genome consensus sequence analysis of a South African rotavirus SA11 sample reveals a mixed infection with two close derivatives of the SA11-H96 strain; Archives of Virology, May, 2013, Vol 158 (5):1021 – 1030.
    18. Jere, K.C., Mlera, L., O Neill, H.G., & van Dijk A.A. Whole genome sequence analyses of three African bovine rotaviruses reveal that they emerged through multiple reassortment events between rotaviruses from different mammalian species; Veterinary Microbiology, Sept 14, 2012, Vol 159: p245 250.
    19. Jere, K.C., Mlera, L., Page, N.A., van Dijk A.A., & O Neill, H.G. Whole genome analysis of multiple rotavirus strains from a single stool specimen using sequence-independent amplification and 454 pyrosequencing reveals evidence of intergenotype genome segment recombination. Infection, Genetics and Evolution Journal, Dec 2011, Vol 11(8): p2072-2082.
    20. Jere, K.C., Mlera, L., O Neill, H.G., Potgieter, C., Page, N.A., Seheri, M.L., & van Dijk A.A. Whole genome analyses of African G2, G8, G9 and G12 rotavirus strains using sequence-independent amplification and 454 pyrosequencing. Journal of Medical Virology, Nov 2011, Vol 83: p2018-2042.
    21. Mlera, L. Jere, K. C., van Dijk, A. A. & H. G. O Neill. Determination of the whole-genome consensus sequence of the prototype DS-1 rotavirus using sequence-independent genome amplification and 454 Journal of Virological Methods; May 2011, Vol 175: 266 – 271.
    22. Jere, K.C., Sawyer, T., Seheri, M., Page, N.A. & Steele, A.D. A first report on the circulating rotavirus strains in Sierra Leone. Journal of Medical Virology Mar 2011, Vol 83:540 – 550.
    23. Fullerton, D., Jere, K., Jambo, K., Kulkarni, N., Zijlstra, E., Grigg, J., French, N., Molyneux, M. & Gordon, S. Domestic smoke exposure is associated with alveolar macrophage particulate load. Tropical Medicine and International Health; March 2009, Vol 14 (3): p349-354.
    24. Gordon, S.B., Malamba, R., Jere, K., Jambo,K., Zijlstra, E., French, N. & Molyneux, M. Inhaled delivery of 23-valent pneumococcal polysaccharide vaccine does not result in enhanced pulmonary mucosal immunoglobulin responses. Vaccine; Oct 2008, Vol 26(42): p5400-6.

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