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Dr Elizabeth Kampira

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Dr Elizabeth Kampira is a senior lecturer in the department of Medical Laboratory Sciences in the faculty of Biomedical Sciences and Health Professionals, College of Meidicine, University of Malawi where she also serves as Deputy Head of Department. She has done extensive work in clinical laboratory sciences, Pharmacogenetics of HIV antiretroviral therapy and validating molecular tool to be used in TB diagnosis. She is a practicing medical laboratory scientist and researcher. She teaches and provides academic mentorship to graduate and undergraduate students especially in Clinical Chemistry, Toxicology and Molecular Diagnostic.

She has contributed in developing curricula of Biomedical Science and Medical Laboratory Science Mzuzu Universities and College of Medicine respectively and its training implementation at College of Medicine in Malawi.

Research Interests

Dr Kampira’s research interest include pharmacogenetic characteristics and pharmacovigilance of the African population with an understanding of drug metabolizing enzymes and transporter genes involved in susceptibility to diseases and variation in response to treatment. Her goal is to intergrate genetic and genomic findings there by promoting monitoring of the safety of drugs in our settings, detection, assessment, understanding into changes in clinical practice, from bench to the bedside and translate the results into better treatment of patients and prevention of adverse drug reactions among patients. I have considerable experience in collaborating in international, multi-center research projects.

Publication

  1. Kampira E, Kumwenda J, Oosterhout J.J, Mbiyavanga M, Nindo F, Elson J, Dandara Characterization of the major Malawian ethnic groups by mitochondrial DNA subhaplogroup distribution: close relationships with south-eastern and southern African Bantu populations. PLos One (In Press)
  2. Carr D.F, Chaponda M, Castro EMC, Jorgesten AL, Khoo S, van Oosterhout JJ, Dandara C, Kampira E, Ssali F, Lalloo DG, Heyderman RS, Pirmohamed M. CYP2B6983T>C polymorphism is associated with nevirapine hypersensitivity in Malawian and Ugandan HIV populations J. Antimicrob. Chemother.(2014) 69 (12):3329-3334
  3. Kampira E, Dzobo K, Kumwenda J, van Oosterhout JJ, Parker IM, Dandara C. Peripheral blood mitochondrial DNA/Nuclear DNA (mtDNA/nDNA) ratio as a marker of mitochondrial toxicities of stavudine containing antiretroviral therapy in HIV-Infected Malawian patients. OMICS J Integrative Biol 2014; 18(7)
  4. Skelton M, Kampira E, Wonkam A, Mhandire K, Kumwenda J, Duri K, Dandara C. BST-2 proximal promoter polymorphisms in sub-Saharan African populations: implications for HIV-1 prevalence. OMICS J Integrative Biol 2014; 18
  5. Kampira E, Kumwenda J, Oosterhout J.J, Dandara C. Mitochondrial DNA subhaplogroups L0a2 and L2a modify susceptibility to peripheral neuropathy in Malawian adults on stavudine containing highly active antiretroviral therapy. J Acquir Immune Def Syndr 2013; 63(5) 647-652
  6. Kampira E, Kumwenda J, Oosterhout J.J, Dandara C. Mitochondria subhaplogroups and differential risk of stavudine-induced lipodystrophyin Malawians HIV/AIDS patients. Pharmacogenetics Pharmacogenomics 201314:16, 1999-2004

  1. van Oosterhout JJ, Gardner K, Mallewa J, Kaunda S, Kampira E, Payne B, Heyderman RS, Chinnery P, Severe toxicity and polymerase- I? gene abnormalities in Malawian adults on stavudine-based antiretroviral therapy. Pharmacogenet Genomics 2013; 23: 624-6
  2. Chagoma N, Mallewa J, Kaunda S, Njalale Y, Kampira E, Mukaka M, Heyderman RS, et al. Longitudinal lactate levels from routine point-of-care monitoring in adult Malawian antiretroviral therapy patients: associations with stavudine toxicities. Trans R Soc Trop Med Hyg 2013; 107: 615-9
  3. Kampira E, Kumwenda J, van Oosterhout J.J, Chaponda M, Dandara C. Pharmacogenetics Research Developments in Africa: A Focus on Malawi. Curr Pharmacogenomics Person Med 2012; 10: 87-97
  4. van Oosterhout JJ, Mallewa J, Kaunda S, Chagoma N, Njalale Y, Kampira E, Mukaka M, Heyderman R. Stavudine toxicity in adult longer-term ART patients in Blantyre, Malawi. PLos One 2012; 16: 2105-17

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