Publications

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This list of publications is for individual members of the group to support their research interests and skills.

Dr Arox Kamng’ona

  1. Chaguza C, Andam CP, Harris SR, Cornick JE, Yang M, Bricio-Moreno L, Kamng’ona AW, Parkhill J, French N, Heyderman RS, Kadioglu A, Everett DB, Bentley SD, Hanage WP. 2016. Recombination in Streptococcus pneumoniae lineages increase with carriage duration and size of the polysaccharide capsule. mBio 7(5):e01053-16. doi:10.1128/mBio.01053-16
  2. Kamng’ona, A.W., Hinds, J., Bar-Zeev, N., Gould, K., Chaguza, C., Msefula, C., Cornick, J.E., Kulohoma, B.W., Gray, K., Bentley, S.D., French, N., Heyderman, R.S., Everett, D.B. 2015. High multiple carriage and emergence of Streptococcus pneumoniae vaccine serotype variants in Malawian children. BMC Infectious Diseases. 15: 234.
  3. Kulohoma, B. W., Gray, K., Kamng’ona, A., Cornick, J., Bentley, S. D., Heyderman, R. S., Everett, D. B. 2013. Piliation of invasive Streptococcus pneumoniae isolates in the era prior to pneumococcal conjugate vaccine introduction, in Malawi. Clinical and Vaccine Immunology. 20(11):1729-35.
  4. Cornick, J. E., Harris, S. R., Parry, C. M., Moore, M. J., Jassi, C., Kamng’ona, A., Kulohoma, B., Heyderman, R. S., Bentley, S. D. & Everett, D. B. 2013. Genomic identification of a novel co-trimoxazole resistance genotype and its prevalence amongst Streptococcus pneumoniae in Malawi. The Journal of antimicrobial chemotherapy. 69(2):368-74.
  5. Glennie, S. J., Banda, D., Gould, K., Hinds, J., Kamngona, A., Everett, D. D., Williams, N. A. & Heyderman, R. S. 2012. Defective Pneumococcal-Specific Th1 Responses in HIVInfected Adults Precedes a Loss of Control of Pneumococcal Colonization. Clinical Infectious Diseases. 56(2):291-9.
  6. Arox Kamng’ona, John P. Moore, George Lindsey, and Wolf Brandt. 2011. Inhibition of HIV-1 and M-MLV reverse transcriptase by a major polyphenol (3,4,5 tri-O-galloylquinic acid) present in the leaves of the South African resurrection plant, Myrothamnus flabellifolia. Journal of Enzyme Inhibition and Medicinal Chemistry. 26(6):843-53.

Dr Benjamin Kumwenda

  1. Kumwenda B, Litthauer D, Tastan-Bishop, O. and Reva O. Factors determining protein thermostability in industrial important Thermus Evolutionary Bioinformatics, 2013; 9:327-342, doi: 10.4137/EBO.S12539
  2. Gounder K., Brzuszkiewicz E., Liesegang H., Wollherr A., Daniel R., Gottschalk G., Reva O., Kumwenda B., Srivastava M., Bricio C., Berenguer J., van Heerden E and Litthauer D. Sequence of the hyperplastic genome of the naturally competent Thermus scotoductus SA-01. BMC Genomics, 2011;12:577 doi:10.1186/1471-2164-12-577
  3. Kumwenda B, Litthauer D, and Reva O. The role of genome rearrangements on adaptation of Thermus species in extreme temperature environments. BMC Genomics, 2014; 15:813; doi:10.1186/1471-2164-15-813
  4. Sarah Rauchas, Ian Sanders, Benjamin Kumwenda. The effect of prior programming experience in a scheme-based breadth-first curriculum at Wits. ACM, Special Interest Group for Computer Science Education (SIGCSE), 2006; 38:3
  5. Benjamin Kumwenda, Dickson Jimmy-Gama, Velia Manyonga, Noella Semu Kamwendo, Beatrice Nindi-Mtotha, and Maureen Chirwa. Factors Affecting Data Quality in the Malawian Health Management Information System. International Association for Science and Technology for Development Health Informatics. 2014 Conference Proceeding. Gaborone, Botswana

Dr Elizabeth Kampira

  1. Kampira E, Kumwenda J, Oosterhout J.J, Mbiyavanga M, Nindo F, Elson J, Dandara Characterization of the major Malawian ethnic groups by mitochondrial DNA subhaplogroup distribution: close relationships with south-eastern and southern African Bantu populations. PLos One (In Press)
  2. Carr D.F, Chaponda M, Castro EMC, Jorgesten AL, Khoo S, van Oosterhout JJ, Dandara C, Kampira E, Ssali F, Lalloo DG, Heyderman RS, Pirmohamed M. CYP2B6983T>C polymorphism is associated with nevirapine hypersensitivity in Malawian and Ugandan HIV populations J. Antimicrob. Chemother. (2014) 69 (12):3329-3334
  3. Kampira E, Dzobo K, Kumwenda J, van Oosterhout JJ, Parker IM, Dandara C. Peripheral blood mitochondrial DNA/Nuclear DNA (mtDNA/nDNA) ratio as a marker of mitochondrial toxicities of stavudine containing antiretroviral therapy in HIV-Infected Malawian patients. OMICS J Integrative Biol 2014; 18(7)
  4. Skelton M, Kampira E, Wonkam A, Mhandire K, Kumwenda J, Duri K, Dandara C. BST-2 proximal promoter polymorphisms in sub-Saharan African populations: implications for HIV-1 prevalence. OMICS J Integrative Biol 2014; 18
  5. Kampira E, Kumwenda J, Oosterhout J.J, Dandara C. Mitochondrial DNA subhaplogroups L0a2 and L2a modify susceptibility to peripheral neuropathy in Malawian adults on stavudine containing highly active antiretroviral therapy. J Acquir Immune Def Syndr 2013; 63(5) 647-652
  6. Kampira E, Kumwenda J, Oosterhout J.J, Dandara C. Mitochondria subhaplogroups and differential risk of stavudine-induced lipodystrophyin Malawians HIV/AIDS patients. Pharmacogenetics Pharmacogenomics 2013 14:16, 1999-2004
  7. van Oosterhout JJ, Gardner K, Mallewa J, Kaunda S, Kampira E, Payne B, Heyderman RS, Chinnery P, Severe toxicity and polymerase- I? gene abnormalities in Malawian adults on stavudine-based antiretroviral therapy. Pharmacogenet Genomics 2013; 23: 624-6
  8. Chagoma N, Mallewa J, Kaunda S, Njalale Y, Kampira E, Mukaka M, Heyderman RS, et al. Longitudinal lactate levels from routine point-of-care monitoring in adult Malawian antiretroviral therapy patients: associations with stavudine toxicities. Trans R Soc Trop Med Hyg 2013; 107: 615-9
  9. Kampira E, Kumwenda J, van Oosterhout J.J, Chaponda M, Dandara C. Pharmacogenetics Research Developments in Africa: A Focus on Malawi. Curr Pharmacogenomics Person Med 2012; 10: 87-97
  10. van Oosterhout JJ, Mallewa J, Kaunda S, Chagoma N, Njalale Y, Kampira E, Mukaka M, Heyderman R. Stavudine toxicity in adult longer-term ART patients in Blantyre, Malawi. PLos One 2012; 16: 2105-17

Dr Chisomo Msefula

  1. Nicholas A. Feasey, Amy K. Cain, Chisomo L. Msefula, Derek Pickard, Maaike Alaerts, Martin Aslett, Dean B. Everett, Theresa J. Allain, Gordon Dougan, Melita A. Gordon, Robert S. Heyderman, and Robert A. Kingsley (2014). Drug resistance in Salmonella enterica ser. Typhimurium Blood stream Infection, Malawi. Emerging Infectious Diseases.20 (11):1957 19592.
  2. Msefula C.L., Kingsley R.A., Gordon M.A., Molyneux E., Molyneux M.E., et al. (2012). Genotypic Homogeneity of Multidrug Resistant S. Typhimurium Infecting Distinct Adult and Childhood Susceptibility Groups in Blantyre, Malawi. PLoSONE 7 (7): e42085.doi:10.1371/journal.pone.
  3. Chinyere K. Okoro, Robert A. Kingsley, Thomas R.Connor, Simon R. Harris, Christopher M. Parry, Samuel Kariuki, Chisomo L. Msefula et al. (2012) Intracontinental spread of human invasive Salmonella Typhimurium pathovariants in sub-Saharan Africa. Nature Genetics 44:1215-1221.
  4. LEE, S.J., L. LIANG, S. JUAREZ, M.R. NANTON, E.N. GONDWE, C.L. MSEFULA et al., 2012 Identification of a common immune signature in murine and human systemic Salmonellosis. Proc Natl Acad Sci USA 109:4998-5003.
  5. Calman A. MacLennan, James J. Gilchrist, Melita A. Gordon, Adam F. Cunningham, Mark C. Cobbold, Margaret Goodall, Robert A. Kingsley, Joep J. G. van Oosterhout, Chisomo L. Msefula, Wilson L. Mandala, Denisse L. Leyton, Esther N. Gondwe, Saeeda Bobat, Ian R. Henderson, Eduard E. Zijlstra, Mark T. Drayson.(2010). Dysregulated humoralimmunity to non-typhoidal Salmonella in HIV-infected African adults. Science 328:508-512.
  6. Robert A. Kingsley, Chisomo L. Msefula, Nicholas R. Thomson, Samuel Kariuki, Kathryn Holt, Melita A.Gordon, Sally Whitehead, Vartul Sangal, Kevin Marsh, Mark Achtman, Malcolm E. Molyneux, Calman A. MacLennan, Robert S. Heyderman and Gordon Dougan (2009). Epidemic multiply drug resistant Salmonella Typhimurium causing invasive disease in Sub-Saharan Africa have a distinct genotype. Genome Research 19 (12):2279-87.
  7. MacLennan C.A., Gondwe E.G., Msefula C.L., Kingsley R.A., Thomson N.R., White S.A., Goodall M., Pickard D.J., Graham S.M., Dougan G., Hart C.A., Molyneux M.E., Drayson (2008). The neglected role of antibody in protection against bacteria caused by nontyphoidal strains of Salmonella in African children. J Clin Invest 118:1553 1562.
  8. Consortium H.A. Research capacity. Enabling the genomic revolution in Africa. Science. 2014;344:1346-89.
  9. S. Kumwenda, C. Msefula and W. Kadewa. Factors that lead to pathogen die-off in ecological sanitation latrines: Are they the same in different places 37 thWEDC International Conference, Hanoi, Vietnam, 2014.